Assay Detail
Binding
CHEMBL1815481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubated for 1 hr measured after 1 hr at 1 min interval by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Proprotein convertase subtilisin/kexin type 7 (CHEMBL2232) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Xylarenones C-E from an endophytic fungus isolated from Alibertia macrophylla.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.61 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813183 | XYLARENONE C | — | 1 | 6.33 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 5.89 |
| CHEMBL1464 | WARFARIN | 4.0 | 1 | 4.61 |
| CHEMBL1813182 | XYLARENONE A | — | 1 | - |
| CHEMBL1813184 | XYLARENONE D | — | 1 | - |
| CHEMBL1813185 | XYLARENONE E | — | 1 | - |
| CHEMBL1813186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813183 | XYLARENONE C | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1464 | WARFARIN | IC50 | = | 24590.0 | nM | 4.61 |
| CHEMBL1813182 | XYLARENONE A | IC50 | - | — | - | |
| CHEMBL1813184 | XYLARENONE D | IC50 | - | — | - | |
| CHEMBL1813185 | XYLARENONE E | IC50 | - | — | - | |
| CHEMBL1813186 | — | IC50 | - | — | - |