Assay Detail
Binding
CHEMBL1815538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5B, mitochondrial (CHEMBL3969) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.51 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189526 | — | — | 1 | 7.64 |
| CHEMBL191045 | — | — | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189526 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL191045 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 54.0 | nM | 7.27 |