Assay Detail
Functional
CHEMBL1815671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Tigliane-type diterpenoid glycosides from Euphorbia fischeriana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.27 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170518 | PROSTRATIN | — | 1 | 10.22 |
| CHEMBL1813584 | — | — | 1 | 9.52 |
| CHEMBL1813583 | FISCHEROSIDES C | — | 1 | 7.70 |
| CHEMBL1813582 | FISCHEROSIDES B | — | 1 | 7.16 |
| CHEMBL1813581 | FISCHEROSIDES A | — | 1 | 6.77 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170518 | PROSTRATIN | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1813584 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1813583 | FISCHEROSIDES C | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1813582 | FISCHEROSIDES B | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1813581 | FISCHEROSIDES A | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 0.004 | nM | - |