Assay Detail
Binding
CHEMBL1815756
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Binding affinity to topoisomerase 1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.56 | 9.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813808 | — | — | 1 | 9.53 |
| CHEMBL1813809 | — | — | 1 | 8.58 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813808 | — | Kd | = | 0.296 | nM | 9.53 |
| CHEMBL1813809 | — | Kd | = | 2.65 | nM | 8.58 |
| CHEMBL84 | TOPOTECAN | Kd | = | 26.5 | nM | 7.58 |