Assay Detail
Binding
CHEMBL1816084
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Inhibition of recombinant EGFR expressed in baculovirus infected Sf9 cells after 1 hr by DELFIA/time-resolved fluorimetry assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.91 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.52 |
| CHEMBL52765 | — | — | 1 | 7.40 |
| CHEMBL1812572 | — | — | 1 | 6.92 |
| CHEMBL1812573 | — | — | 1 | 6.72 |
| CHEMBL343352 | — | — | 1 | 6.70 |
| CHEMBL1812571 | — | — | 1 | 6.03 |
| CHEMBL1812560 | — | — | 1 | 5.99 |
| CHEMBL1812431 | — | — | 1 | 5.92 |
| CHEMBL1812569 | — | — | 1 | 5.55 |
| CHEMBL1812570 | — | — | 1 | 5.46 |
| CHEMBL1812564 | — | — | 1 | 5.46 |
| CHEMBL1812561 | — | — | 1 | 5.44 |
| CHEMBL1812434 | — | — | 1 | 5.37 |
| CHEMBL1812559 | — | — | 1 | 5.29 |
| CHEMBL1812556 | — | — | 1 | 5.22 |
| CHEMBL1812566 | — | — | 1 | 5.18 |
| CHEMBL1812435 | — | — | 1 | 5.14 |
| CHEMBL1812555 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL52765 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1812572 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1812573 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL343352 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1812571 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1812560 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1812431 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1812569 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL1812570 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1812564 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL1812561 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL1812434 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL1812559 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL1812556 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL1812566 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL1812435 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL1812555 | — | IC50 | = | 7710.0 | nM | 5.11 |