Assay Detail
Binding
CHEMBL1816233
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Inhibition of BChE by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 10.51 | 10.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814730 | — | — | 1 | 10.67 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 10.57 |
| CHEMBL1814731 | — | — | 1 | 10.45 |
| CHEMBL1814729 | — | — | 1 | 10.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814730 | — | IC50 | = | 0.0212 | nM | 10.67 |
| CHEMBL95 | TACRINE | IC50 | = | 0.0267 | nM | 10.57 |
| CHEMBL1814731 | — | IC50 | = | 0.0354 | nM | 10.45 |
| CHEMBL1814729 | — | IC50 | = | 0.0449 | nM | 10.35 |