Assay Detail
Functional
CHEMBL1816640
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Antiproliferative activity against rat LT12 cells after 48 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | LT12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.58 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238071 | VINDESINE | 3.0 | 1 | 9.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.22 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.40 |
| CHEMBL1814612 | — | — | 1 | 6.75 |
| CHEMBL1814615 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238071 | VINDESINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1814612 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1814615 | — | IC50 | = | 310.0 | nM | 6.51 |