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Assay Detail

CHEMBL1816743

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Binding
Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2111354)
Type PROTEIN FAMILY
Organism Sus scrofa

Publication

Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.
Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Günther EG, Unger E.
Bioorg Med Chem (2011) 19 : 4183 -4191
PubMed 21705223 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.02 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378544 VINBLASTINE SULFATE 4.0 1 6.89
CHEMBL61 PODOFILOX 4.0 1 6.46
CHEMBL1814612 1 6.36
CHEMBL9514 NOCODAZOLE 2.0 1 6.12
CHEMBL1814615 1 5.96
CHEMBL107 COLCHICINE 4.0 1 5.85
CHEMBL1814605 1 5.84
CHEMBL1814608 1 5.80
CHEMBL1814609 1 5.80
CHEMBL1814606 1 5.72
CHEMBL1814607 1 5.44
CHEMBL1814614 1 -
CHEMBL1814616 1 -
CHEMBL1814617 1 -
CHEMBL1814618 1 -
CHEMBL1814619 1 -
CHEMBL1814620 1 -
CHEMBL1814613 1 -
CHEMBL1814611 1 -
CHEMBL1814610 1 -
CHEMBL53463 DOXORUBICIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378544 VINBLASTINE SULFATE IC50 = 130.0 nM 6.89
CHEMBL61 PODOFILOX IC50 = 350.0 nM 6.46
CHEMBL1814612 IC50 = 440.0 nM 6.36
CHEMBL9514 NOCODAZOLE IC50 = 760.0 nM 6.12
CHEMBL1814615 IC50 = 1110.0 nM 5.96
CHEMBL107 COLCHICINE IC50 = 1400.0 nM 5.85
CHEMBL1814605 IC50 = 1450.0 nM 5.84
CHEMBL1814608 IC50 = 1600.0 nM 5.80
CHEMBL1814609 IC50 = 1600.0 nM 5.80
CHEMBL1814606 IC50 = 1900.0 nM 5.72
CHEMBL1814607 IC50 = 3600.0 nM 5.44
CHEMBL1814614 IC50 - -
CHEMBL1814616 IC50 > 10000.0 nM -
CHEMBL1814617 IC50 > 10000.0 nM -
CHEMBL1814618 IC50 > 10000.0 nM -
CHEMBL1814619 IC50 > 10000.0 nM -
CHEMBL1814620 IC50 > 10000.0 nM -
CHEMBL1814613 IC50 - -
CHEMBL1814611 IC50 > 10000.0 nM -
CHEMBL1814610 IC50 - -
CHEMBL53463 DOXORUBICIN IC50 - -