Assay Detail
Binding
CHEMBL1816746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells by high throughput single cell planar patch clamp method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.33 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813315 | — | — | 1 | 5.63 |
| CHEMBL1813472 | — | — | 1 | 5.44 |
| CHEMBL1813314 | — | — | 1 | 5.38 |
| CHEMBL1813317 | — | — | 1 | 5.36 |
| CHEMBL1813316 | — | — | 1 | 5.33 |
| CHEMBL1813475 | — | — | 1 | 5.28 |
| CHEMBL1813484 | — | — | 1 | 5.26 |
| CHEMBL1813478 | — | — | 1 | 5.25 |
| CHEMBL1813474 | — | — | 1 | 5.19 |
| CHEMBL1813471 | — | — | 1 | 5.19 |
| CHEMBL1813485 | — | — | 1 | - |
| CHEMBL1813483 | — | — | 1 | - |
| CHEMBL1813477 | — | — | 1 | - |
| CHEMBL1813476 | — | — | 1 | - |
| CHEMBL1813489 | — | — | 1 | - |
| CHEMBL1813487 | — | — | 1 | - |
| CHEMBL1813470 | — | — | 1 | - |
| CHEMBL1813313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813315 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL1813472 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL1813314 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL1813317 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL1813316 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL1813475 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL1813484 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL1813478 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL1813474 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1813471 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL1813485 | — | IC50 | - | — | - | |
| CHEMBL1813483 | — | IC50 | - | — | - | |
| CHEMBL1813477 | — | IC50 | - | — | - | |
| CHEMBL1813476 | — | IC50 | - | — | - | |
| CHEMBL1813489 | — | IC50 | - | — | - | |
| CHEMBL1813487 | — | IC50 | - | — | - | |
| CHEMBL1813470 | — | IC50 | - | — | - | |
| CHEMBL1813313 | — | IC50 | - | — | - |