Assay Detail
Binding
CHEMBL1816807
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Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-acyl-carrier protein reductase (CHEMBL4150) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.12 | 6.70 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 6.70 |
| CHEMBL1812485 | MUCUSISOFLAVONE C | — | 1 | 5.11 |
| CHEMBL163316 | 3-O-METHYLQUERCETIN | — | 1 | 4.45 |
| CHEMBL1271888 | ISOWIGHTEONE | — | 1 | 4.23 |
| CHEMBL1812483 | MUCUSISOFLAVONE A | — | 1 | - |
| CHEMBL1812484 | MUCUSISOFLAVONE B | — | 1 | - |
| CHEMBL589522 | — | — | 1 | - |
| CHEMBL21932 | p-ANISIC ACID | — | 1 | - |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | - |
| CHEMBL238628 | ALPINUMISOFLAVONE | — | 1 | - |
| CHEMBL393222 | WIGHTEONE | — | 1 | - |
| CHEMBL459201 | ISODERRONE | — | 1 | - |
| CHEMBL1812593 | ISOWIGHTEONE HYDRATE | — | 1 | - |
| CHEMBL1812594 | BENJAMINAMIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1812485 | MUCUSISOFLAVONE C | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL163316 | 3-O-METHYLQUERCETIN | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL1271888 | ISOWIGHTEONE | IC50 | = | 58950.0 | nM | 4.23 |
| CHEMBL1812483 | MUCUSISOFLAVONE A | Inhibition | - | % | - | |
| CHEMBL1812484 | MUCUSISOFLAVONE B | Inhibition | - | % | - | |
| CHEMBL589522 | — | IC50 | - | — | - | |
| CHEMBL21932 | p-ANISIC ACID | Inhibition | - | % | - | |
| CHEMBL150 | KAEMPFEROL | IC50 | - | — | - | |
| CHEMBL238628 | ALPINUMISOFLAVONE | IC50 | - | — | - | |
| CHEMBL393222 | WIGHTEONE | IC50 | - | — | - | |
| CHEMBL459201 | ISODERRONE | IC50 | - | — | - | |
| CHEMBL1812593 | ISOWIGHTEONE HYDRATE | IC50 | = | 248300.0 | nM | - |
| CHEMBL1812594 | BENJAMINAMIDE | Inhibition | - | % | - |