Assay Detail
Binding
CHEMBL1816904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.62 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814759 | — | — | 1 | 7.48 |
| CHEMBL1814757 | — | — | 1 | 6.77 |
| CHEMBL3216065 | — | — | 1 | 6.54 |
| CHEMBL1814758 | — | — | 1 | 6.19 |
| CHEMBL1814751 | — | — | 1 | 5.72 |
| CHEMBL1814755 | — | — | 1 | 5.68 |
| CHEMBL1814745 | — | — | 1 | 5.48 |
| CHEMBL1814760 | — | — | 1 | 5.44 |
| CHEMBL1814737 | — | — | 1 | 4.85 |
| CHEMBL1814632 | — | — | 1 | 4.82 |
| CHEMBL1814752 | — | — | 1 | 4.76 |
| CHEMBL1814634 | — | — | 1 | 4.71 |
| CHEMBL1814754 | — | — | 1 | 4.64 |
| CHEMBL1814633 | — | — | 1 | - |
| CHEMBL1814738 | — | — | 1 | - |
| CHEMBL1814739 | — | — | 1 | - |
| CHEMBL1814740 | — | — | 1 | - |
| CHEMBL1814741 | — | — | 1 | - |
| CHEMBL3216066 | — | — | 1 | - |
| CHEMBL1814743 | — | — | 1 | - |
| CHEMBL1814744 | — | — | 1 | - |
| CHEMBL3215830 | — | — | 1 | - |
| CHEMBL1814747 | — | — | 1 | - |
| CHEMBL1814748 | — | — | 1 | - |
| CHEMBL1814749 | — | — | 1 | - |
| CHEMBL3216276 | — | — | 1 | - |
| CHEMBL1814753 | — | — | 1 | - |
| CHEMBL1811949 | — | — | 1 | - |
| CHEMBL1814756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814759 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1814757 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3216065 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1814758 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1814751 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1814755 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1814745 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1814760 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1814737 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1814632 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1814752 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1814634 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL1814754 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1814633 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1814738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1814739 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1814740 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1814741 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3216066 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1814743 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1814744 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3215830 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1814747 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1814748 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1814749 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3216276 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1814753 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1811949 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1814756 | — | IC50 | > | 100000.0 | nM | - |