Assay Detail
Binding
CHEMBL1816913
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Inhibition of DPP9
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.85 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814633 | — | — | 1 | 7.28 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 6.17 |
| CHEMBL98869 | — | — | 1 | 4.11 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814633 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL98869 | — | IC50 | = | 78600.0 | nM | 4.11 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | > | 100000.0 | nM | - |