Assay Detail
Binding
CHEMBL1817022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human platelet-type 12-lipoxygenase
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.73 | 6.96 |
| Ki | 1 | 5.80 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.96 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.80 |
| CHEMBL362761 | — | — | 1 | 5.75 |
| CHEMBL184398 | — | — | 1 | 5.30 |
| CHEMBL381149 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL8260 | BAICALEIN | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL362761 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL184398 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL381149 | — | IC50 | = | 12300.0 | nM | 4.91 |