Assay Detail
Functional
CHEMBL1817045
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Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.51 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1812161 | VATIQUINONE | 3.0 | 1 | 7.62 |
| CHEMBL252556 | IDEBENONE | 4.0 | 1 | 6.07 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1812161 | VATIQUINONE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL252556 | IDEBENONE | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL165 | RESVERATROL | EC50 | = | 1440.0 | nM | 5.84 |