Assay Detail
Functional
CHEMBL1817061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at non-desensitized homomeric rat GluK3 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.35 | 4.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288166 | 2S,4R-4-METHYLGLUTAMATE | — | 1 | 4.35 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288166 | 2S,4R-4-METHYLGLUTAMATE | EC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 9030000.0 | nM | - |