Assay Detail
Functional
CHEMBL1817187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CEM-DNR-bulk cells after 3 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-DNR-bulk |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.09 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814773 | — | — | 1 | 8.10 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.66 |
| CHEMBL1814768 | — | — | 1 | 7.04 |
| CHEMBL1814774 | — | — | 1 | 6.98 |
| CHEMBL1814770 | — | — | 1 | 6.96 |
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 6.45 |
| CHEMBL1814769 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814773 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1814768 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1814774 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL1814770 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1619 | CLADRIBINE | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL1814769 | — | IC50 | = | 364.0 | nM | 6.44 |