Assay Detail
Binding
CHEMBL1817449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formylkynurenine into kynurenine after 30 mins by Michaelis-Menten steady state analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.27 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355606 | — | — | 1 | 6.06 |
| CHEMBL1812545 | — | — | 1 | 5.25 |
| CHEMBL1812547 | — | — | 1 | 4.49 |
| CHEMBL54976 | TRYPTOPHAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355606 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL1812545 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL1812547 | — | Ki | = | 32400.0 | nM | 4.49 |
| CHEMBL54976 | TRYPTOPHAN | Ki | = | 11500000.0 | nM | - |