Assay Detail
Functional
CHEMBL1817475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative ionotropic activity against potassium-induced contraction in guinea pig left atrium assessed as decrease atrial rate
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.88 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814700 | — | — | 1 | 8.66 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 7.55 |
| CHEMBL1814699 | — | — | 1 | 7.54 |
| CHEMBL1814583 | — | — | 1 | 7.51 |
| CHEMBL1814576 | — | — | 1 | 7.48 |
| CHEMBL1814701 | — | — | 1 | 7.47 |
| CHEMBL1814575 | — | — | 1 | 6.92 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 6.58 |
| CHEMBL1814577 | — | — | 1 | 6.57 |
| CHEMBL1814582 | — | — | 1 | 6.47 |
| CHEMBL1814581 | — | — | 1 | 6.41 |
| CHEMBL1814584 | — | — | 1 | 6.37 |
| CHEMBL1814579 | — | — | 1 | 6.14 |
| CHEMBL1814574 | — | — | 1 | 5.97 |
| CHEMBL1814578 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814700 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL44 | GENISTEIN | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1814699 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1814583 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1814576 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1814701 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1814575 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL193 | NIFEDIPINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1814577 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1814582 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1814581 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1814584 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1814579 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1814574 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1814578 | — | EC50 | = | 2330.0 | nM | 5.63 |