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Assay Detail

CHEMBL1820229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B colorimetric assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Autocuration

Target

NIH3T3 (CHEMBL614822)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and antimicrobial activity of (E) stilbene derivatives.
Albert S, Horbach R, Deising HB, Siewert B, Csuk R.
Bioorg Med Chem (2011) 19 : 5155 -5166
PubMed 21803587 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.08 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL419378 1 6.70
CHEMBL1817670 1 5.68
CHEMBL1817791 1 5.16
CHEMBL1817793 1 5.13
CHEMBL1817795 1 5.09
CHEMBL1817794 1 5.02
CHEMBL1817800 1 4.98
CHEMBL1817790 1 4.94
CHEMBL1817796 1 4.93
CHEMBL83527 PTEROSTILBENE 2.0 1 4.91
CHEMBL1817804 1 4.91
CHEMBL1817802 1 4.83
CHEMBL1817801 1 4.71
CHEMBL1817806 1 4.68
CHEMBL1817799 1 4.59
CHEMBL1817797 1 -
CHEMBL1817798 1 -
CHEMBL99852 1 -
CHEMBL1817803 1 -
CHEMBL175736 1 -
CHEMBL1817805 1 -
CHEMBL1817807 1 -
CHEMBL1817792 1 -
CHEMBL1817808 1 -
CHEMBL165 RESVERATROL 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL419378 IC50 = 200.0 nM 6.70
CHEMBL1817670 IC50 = 2100.0 nM 5.68
CHEMBL1817791 IC50 = 6900.0 nM 5.16
CHEMBL1817793 IC50 = 7400.0 nM 5.13
CHEMBL1817795 IC50 = 8200.0 nM 5.09
CHEMBL1817794 IC50 = 9600.0 nM 5.02
CHEMBL1817800 IC50 = 10500.0 nM 4.98
CHEMBL1817790 IC50 = 11500.0 nM 4.94
CHEMBL1817796 IC50 = 11800.0 nM 4.93
CHEMBL83527 PTEROSTILBENE IC50 = 12200.0 nM 4.91
CHEMBL1817804 IC50 = 12400.0 nM 4.91
CHEMBL1817802 IC50 = 14800.0 nM 4.83
CHEMBL1817801 IC50 = 19600.0 nM 4.71
CHEMBL1817806 IC50 = 21100.0 nM 4.68
CHEMBL1817799 IC50 = 25800.0 nM 4.59
CHEMBL1817797 IC50 > 30000.0 nM -
CHEMBL1817798 IC50 > 30000.0 nM -
CHEMBL99852 IC50 > 30000.0 nM -
CHEMBL1817803 IC50 > 30000.0 nM -
CHEMBL175736 IC50 > 30000.0 nM -
CHEMBL1817805 IC50 > 30000.0 nM -
CHEMBL1817807 IC50 > 30000.0 nM -
CHEMBL1817792 IC50 > 30000.0 nM -
CHEMBL1817808 IC50 > 30000.0 nM -
CHEMBL165 RESVERATROL IC50 > 24200.0 nM -