Assay Detail
Binding
CHEMBL1820356
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Inhibition of human serum recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.41 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 9.09 |
| CHEMBL1819176 | — | — | 1 | 8.98 |
| CHEMBL1819177 | — | — | 1 | 7.92 |
| CHEMBL1819175 | — | — | 1 | 7.86 |
| CHEMBL1819171 | — | — | 1 | 7.78 |
| CHEMBL1819173 | — | — | 1 | 7.55 |
| CHEMBL1819172 | — | — | 1 | 7.47 |
| CHEMBL1819170 | — | — | 1 | 7.35 |
| CHEMBL1819169 | — | — | 1 | 7.16 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.60 |
| CHEMBL1819179 | — | — | 1 | 6.59 |
| CHEMBL1819174 | — | — | 1 | 6.55 |
| CHEMBL1819178 | — | — | 1 | 6.51 |
| CHEMBL1819180 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1819176 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL1819177 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL1819175 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL1819171 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL1819173 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL1819172 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1819170 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL1819169 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL95 | TACRINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1819179 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL1819174 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL1819178 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1819180 | — | IC50 | = | 455.0 | nM | 6.34 |