Assay Detail
Binding
CHEMBL1820876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.00 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 6.29 |
| CHEMBL369297 | — | — | 1 | 4.75 |
| CHEMBL501385 | — | — | 1 | 4.47 |
| CHEMBL108084 | FAGOMINE | — | 1 | 4.47 |
| CHEMBL1818436 | — | — | 1 | - |
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL369297 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL501385 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL108084 | FAGOMINE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1818436 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 531000.0 | nM | - |