Assay Detail
Binding
CHEMBL1820879
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Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate by spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.65 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456583 | — | — | 1 | 5.25 |
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | 4.51 |
| CHEMBL1818433 | — | — | 1 | 4.20 |
| CHEMBL501385 | — | — | 1 | - |
| CHEMBL1818432 | — | — | 1 | - |
| CHEMBL108084 | FAGOMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456583 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1818433 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL501385 | — | IC50 | = | 611000.0 | nM | - |
| CHEMBL1818432 | — | IC50 | = | 676000.0 | nM | - |
| CHEMBL108084 | FAGOMINE | IC50 | = | 250000.0 | nM | - |