Assay Detail
Functional
CHEMBL1820935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 LAI-3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.58 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 9.68 |
| CHEMBL1818956 | — | — | 1 | 6.89 |
| CHEMBL1818949 | — | — | 1 | 5.50 |
| CHEMBL1818952 | — | — | 1 | 5.49 |
| CHEMBL1818945 | — | — | 1 | 5.45 |
| CHEMBL1818953 | — | — | 1 | 5.31 |
| CHEMBL1818950 | — | — | 1 | 5.26 |
| CHEMBL1818955 | — | — | 1 | 5.24 |
| CHEMBL1818951 | — | — | 1 | 5.19 |
| CHEMBL1818947 | — | — | 1 | 5.15 |
| CHEMBL1818954 | — | — | 1 | 5.03 |
| CHEMBL1818944 | — | — | 1 | 4.69 |
| CHEMBL1818948 | — | — | 1 | 4.68 |
| CHEMBL1818946 | — | — | 1 | 4.60 |
| CHEMBL1818943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL1818956 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1818949 | — | EC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL1818952 | — | EC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL1818945 | — | EC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL1818953 | — | EC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL1818950 | — | EC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL1818955 | — | EC50 | = | 5740.0 | nM | 5.24 |
| CHEMBL1818951 | — | EC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL1818947 | — | EC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL1818954 | — | EC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL1818944 | — | EC50 | = | 20480.0 | nM | 4.69 |
| CHEMBL1818948 | — | EC50 | = | 20870.0 | nM | 4.68 |
| CHEMBL1818946 | — | EC50 | = | 24930.0 | nM | 4.60 |
| CHEMBL1818943 | — | EC50 | = | 307570.0 | nM | - |