Assay Detail
Functional
CHEMBL1820936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 A17 harboring reverse transcriptase Y181C mutant infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.02 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 9.00 |
| CHEMBL1818956 | — | — | 1 | 7.07 |
| CHEMBL1818949 | — | — | 1 | 4.75 |
| CHEMBL1818953 | — | — | 1 | 4.72 |
| CHEMBL1818954 | — | — | 1 | 4.65 |
| CHEMBL1818952 | — | — | 1 | 4.62 |
| CHEMBL1818955 | — | — | 1 | 4.62 |
| CHEMBL1818951 | — | — | 1 | 4.57 |
| CHEMBL1818950 | — | — | 1 | 4.53 |
| CHEMBL1818946 | — | — | 1 | 4.48 |
| CHEMBL1818947 | — | — | 1 | 4.48 |
| CHEMBL1818944 | — | — | 1 | 4.36 |
| CHEMBL1818948 | — | — | 1 | 4.29 |
| CHEMBL1818945 | — | — | 1 | 4.17 |
| CHEMBL1818943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1818956 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1818949 | — | EC50 | = | 17880.0 | nM | 4.75 |
| CHEMBL1818953 | — | EC50 | = | 19080.0 | nM | 4.72 |
| CHEMBL1818954 | — | EC50 | = | 22520.0 | nM | 4.65 |
| CHEMBL1818952 | — | EC50 | = | 24230.0 | nM | 4.62 |
| CHEMBL1818955 | — | EC50 | = | 24250.0 | nM | 4.62 |
| CHEMBL1818951 | — | EC50 | = | 27220.0 | nM | 4.57 |
| CHEMBL1818950 | — | EC50 | = | 29250.0 | nM | 4.53 |
| CHEMBL1818946 | — | EC50 | = | 32810.0 | nM | 4.48 |
| CHEMBL1818947 | — | EC50 | = | 33240.0 | nM | 4.48 |
| CHEMBL1818944 | — | EC50 | = | 43680.0 | nM | 4.36 |
| CHEMBL1818948 | — | EC50 | = | 51190.0 | nM | 4.29 |
| CHEMBL1818945 | — | EC50 | = | 67880.0 | nM | 4.17 |
| CHEMBL1818943 | — | EC50 | - | — | - |