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Assay Detail

CHEMBL1821189

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ADMET
Cytotoxicity against RAOSMC after 3 days by cell counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides.
Ferri N, Radice T, Antonino M, Beccalli EM, Tinelli S, Zunino F, Corsini A, Pratesi G, Ragg EM, Gelmi ML, Contini A.
Bioorg Med Chem (2011) 19 : 5291 -5299
PubMed 21880496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.11 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31400 ELINAFIDE 2.0 1 7.92
CHEMBL1819600 1 7.05
CHEMBL1819602 1 6.64
CHEMBL1819598 1 6.21
CHEMBL1819533 1 6.14
CHEMBL1819539 1 6.00
CHEMBL1819535 1 5.89
CHEMBL1819534 1 5.75
CHEMBL1819536 1 5.46
CHEMBL1819538 1 5.33
CHEMBL1819537 1 4.78
CHEMBL1819599 1 -
CHEMBL1819601 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31400 ELINAFIDE IC50 = 12.0 nM 7.92
CHEMBL1819600 IC50 = 90.0 nM 7.05
CHEMBL1819602 IC50 = 230.0 nM 6.64
CHEMBL1819598 IC50 = 620.0 nM 6.21
CHEMBL1819533 IC50 = 730.0 nM 6.14
CHEMBL1819539 IC50 = 1000.0 nM 6.00
CHEMBL1819535 IC50 = 1300.0 nM 5.89
CHEMBL1819534 IC50 = 1800.0 nM 5.75
CHEMBL1819536 IC50 = 3500.0 nM 5.46
CHEMBL1819538 IC50 = 4700.0 nM 5.33
CHEMBL1819537 IC50 = 16500.0 nM 4.78
CHEMBL1819599 IC50 > 30000.0 nM -
CHEMBL1819601 IC50 > 30000.0 nM -