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Assay Detail

CHEMBL1821396

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Binding
Inhibition of Escherichia coli DdlB assessed as residual activity of the enzyme assessed as orthophosphate formation after 20 mins by malachite green reagent method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase.
Vehar B, Hrast M, Kovač A, Konc J, Mariner K, Chopra I, O'Neill A, Janežič D, Gobec S.
Bioorg Med Chem (2011) 19 : 5137 -5146
PubMed 21831641 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.25 4.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1818244 1 4.64
CHEMBL1818135 1 4.50
CHEMBL1818243 1 4.44
CHEMBL67592 1 4.37
CHEMBL69233 1 4.34
CHEMBL19954 1 4.22
CHEMBL1818247 1 4.19
CHEMBL68096 1 4.19
CHEMBL363332 1 4.16
CHEMBL194474 1 4.07
CHEMBL1818239 1 4.05
CHEMBL1818246 1 4.05
CHEMBL305589 1 4.05
CHEMBL1818130 1 -
CHEMBL1818131 1 -
CHEMBL1818132 1 -
CHEMBL1818133 1 -
CHEMBL1818134 1 -
CHEMBL1312050 1 -
CHEMBL3216953 1 -
CHEMBL26559 1 -
CHEMBL304910 1 -
CHEMBL1818248 1 -
CHEMBL1818242 1 -
CHEMBL463783 1 -
CHEMBL1818245 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1818244 IC50 = 23000.0 nM 4.64
CHEMBL1818135 IC50 = 32000.0 nM 4.50
CHEMBL1818243 IC50 = 36000.0 nM 4.44
CHEMBL67592 IC50 = 43000.0 nM 4.37
CHEMBL69233 IC50 = 46000.0 nM 4.34
CHEMBL19954 IC50 = 60000.0 nM 4.22
CHEMBL1818247 IC50 = 64000.0 nM 4.19
CHEMBL68096 IC50 = 65000.0 nM 4.19
CHEMBL363332 IC50 = 70000.0 nM 4.16
CHEMBL194474 IC50 = 86000.0 nM 4.07
CHEMBL1818239 IC50 = 90000.0 nM 4.05
CHEMBL1818246 IC50 = 90000.0 nM 4.05
CHEMBL305589 IC50 = 89000.0 nM 4.05
CHEMBL1818130 IC50 = 320000.0 nM -
CHEMBL1818131 IC50 = 161000.0 nM -
CHEMBL1818132 IC50 = 102000.0 nM -
CHEMBL1818133 IC50 = 119000.0 nM -
CHEMBL1818134 IC50 = 135000.0 nM -
CHEMBL1312050 IC50 = 623000.0 nM -
CHEMBL3216953 IC50 = 330000.0 nM -
CHEMBL26559 IC50 = 192000.0 nM -
CHEMBL304910 IC50 = 184000.0 nM -
CHEMBL1818248 IC50 = 125000.0 nM -
CHEMBL1818242 IC50 = 297000.0 nM -
CHEMBL463783 IC50 = 162000.0 nM -
CHEMBL1818245 IC50 = 103000.0 nM -