Assay Detail
Functional
CHEMBL1825296
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Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.94 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 8.14 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | 4.0 | 1 | 7.43 |
| CHEMBL1467585 | — | — | 1 | 7.25 |
| CHEMBL1822918 | — | — | 1 | 6.36 |
| CHEMBL1822919 | — | — | 1 | 6.24 |
| CHEMBL1822920 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1467585 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1822918 | — | EC50 | = | 438.0 | nM | 6.36 |
| CHEMBL1822919 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1822920 | — | EC50 | = | 584.0 | nM | 6.23 |