Assay Detail
Functional
CHEMBL1825299
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Antiproliferative activity against human A549 cells after 72 hrs by SRB method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.53 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822924 | — | — | 1 | 8.98 |
| CHEMBL1822922 | — | — | 1 | 8.92 |
| CHEMBL1822925 | — | — | 1 | 8.58 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.50 |
| CHEMBL1822923 | — | — | 1 | 8.43 |
| CHEMBL1822921 | — | — | 1 | 8.25 |
| CHEMBL364447 | DISERMOLIDE | 2.0 | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822924 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL1822922 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL1822925 | — | IC50 | = | 2.64 | nM | 8.58 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.14 | nM | 8.50 |
| CHEMBL1822923 | — | IC50 | = | 3.76 | nM | 8.43 |
| CHEMBL1822921 | — | IC50 | = | 5.61 | nM | 8.25 |
| CHEMBL364447 | DISERMOLIDE | IC50 | = | 9.34 | nM | 8.03 |