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Compound Detail

CHEMBL1822922

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C=C/C=C\[C@H](C)[C@H](OC(=O)NCCCNC(=O)c1ccc(N=[N+]=[N-])cc1)[C@@H](C)[C@H](O)[C@@H](C)C/C(C)=C\[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C

Basic Information

ChEMBL ID CHEMBL1822922
Phase Preclinical
Structure Type MOL
InChI Key XRAYLROIHMRABV-KMZISQKGSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names

Molecular Properties

796.0
MW (Da)
6.69
ALogP
10
HBA
6
HBD
223.4
PSA (Ų)
0.01
QED
3
Ro5 Violations
22
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C43H65N5O9
MW 796.02
Aromatic Rings 1
Heavy Atoms 57
NP-Likeness 1.59

Activity Summary

IC50 2 meas. best 8.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
A549
CHEMBL392
IC50 8.92 8.92 1.2 1
MCF7
CHEMBL387
IC50 8.72 8.72 1.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine