Assay Detail
Binding
CHEMBL1825435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutathione reductase, mitochondrial (CHEMBL2755) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.08 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824793 | — | — | 1 | 6.68 |
| CHEMBL1824792 | — | — | 1 | 5.34 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 4.76 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.37 |
| CHEMBL8085 | LYSINE | 2.0 | 1 | 4.26 |
| CHEMBL15750 | NITROBENZENE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824793 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL1824792 | — | Ki | = | 4570.0 | nM | 5.34 |
| CHEMBL193 | NIFEDIPINE | Ki | = | 17400.0 | nM | 4.76 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 42700.0 | nM | 4.37 |
| CHEMBL8085 | LYSINE | Ki | = | 54600.0 | nM | 4.26 |
| CHEMBL15750 | NITROBENZENE | Ki | = | 274100.0 | nM | - |