Assay Detail
Binding
CHEMBL1825474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indolin-2-one p38α inhibitors II: Lead optimisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.44 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1825149 | — | — | 1 | 10.10 |
| CHEMBL1825148 | — | — | 1 | 10.05 |
| CHEMBL1825157 | — | — | 1 | 9.10 |
| CHEMBL1825154 | — | — | 1 | 9.05 |
| CHEMBL1825146 | — | — | 1 | 9.00 |
| CHEMBL1825151 | — | — | 1 | 8.85 |
| CHEMBL1825152 | — | — | 1 | 8.85 |
| CHEMBL1825147 | — | — | 1 | 8.78 |
| CHEMBL1825158 | — | — | 1 | 8.74 |
| CHEMBL1825153 | — | — | 1 | 8.74 |
| CHEMBL1825160 | — | — | 1 | 8.64 |
| CHEMBL1825145 | — | — | 1 | 8.28 |
| CHEMBL1825156 | — | — | 1 | 8.25 |
| CHEMBL1825150 | — | — | 1 | 8.17 |
| CHEMBL1825155 | — | — | 1 | 8.13 |
| CHEMBL1825159 | — | — | 1 | 7.89 |
| CHEMBL1825161 | — | — | 1 | 7.21 |
| CHEMBL1825162 | — | — | 1 | 7.14 |
| CHEMBL1825144 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1825149 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1825148 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1825157 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1825154 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1825146 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1825151 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1825152 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1825147 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL1825158 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1825153 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1825160 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1825145 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1825156 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1825150 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1825155 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL1825159 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1825161 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1825162 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1825144 | — | IC50 | = | 4570.0 | nM | 5.34 |