Assay Detail
Binding
CHEMBL1825596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant JNK3 using ser73 of c-jun as substrate preincubated for 15 mins measured after 60 mins by TR-FRET assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822151 | — | — | 1 | 8.70 |
| CHEMBL1822152 | — | — | 1 | 8.70 |
| CHEMBL1822305 | — | — | 1 | 8.52 |
| CHEMBL1822145 | — | — | 1 | 8.30 |
| CHEMBL1822153 | — | — | 1 | 8.22 |
| CHEMBL1822149 | — | — | 1 | 8.22 |
| CHEMBL1822139 | — | — | 1 | 8.22 |
| CHEMBL1822141 | — | — | 1 | 8.22 |
| CHEMBL1822140 | — | — | 1 | 8.15 |
| CHEMBL1822309 | — | — | 1 | 8.10 |
| CHEMBL1822307 | — | — | 1 | 8.10 |
| CHEMBL1822143 | — | — | 1 | 8.10 |
| CHEMBL1822308 | — | — | 1 | 8.05 |
| CHEMBL1822147 | — | — | 1 | 8.05 |
| CHEMBL1822146 | — | — | 1 | 8.05 |
| CHEMBL1822306 | — | — | 1 | 7.96 |
| CHEMBL1822144 | — | — | 1 | 7.85 |
| CHEMBL1822138 | — | — | 1 | 7.85 |
| CHEMBL1822142 | — | — | 1 | 7.85 |
| CHEMBL1822154 | — | — | 1 | 7.82 |
| CHEMBL1822150 | — | — | 1 | 7.72 |
| CHEMBL1822132 | — | — | 1 | 7.62 |
| CHEMBL1682013 | — | — | 1 | 7.55 |
| CHEMBL1822133 | — | — | 1 | 7.52 |
| CHEMBL1822134 | — | — | 1 | 7.39 |
| CHEMBL1822135 | — | — | 1 | 7.28 |
| CHEMBL1822148 | — | — | 1 | 7.15 |
| CHEMBL1822137 | — | — | 1 | 6.74 |
| CHEMBL1822136 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822151 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1822152 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1822305 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1822145 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1822153 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1822149 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1822139 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1822141 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1822140 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1822309 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1822307 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1822143 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1822308 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1822147 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1822146 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1822306 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1822144 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1822138 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1822142 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1822154 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1822150 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1822132 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1682013 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1822133 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1822134 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1822135 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1822148 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1822137 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL1822136 | — | IC50 | = | 280.0 | nM | 6.55 |