Assay Detail
Functional
CHEMBL1825883
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Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.95 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 9.30 |
| CHEMBL1821968 | — | — | 1 | 6.44 |
| CHEMBL1821973 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1821968 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1821973 | — | IC50 | = | 7600.0 | nM | 5.12 |