Assay Detail
Binding
CHEMBL1826107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-pentazocine from sigma 1 receptor from guinea pig brain membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.64 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 9.42 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 8.58 |
| CHEMBL1822599 | — | — | 1 | 8.04 |
| CHEMBL1822600 | — | — | 1 | 7.70 |
| CHEMBL1822597 | — | — | 1 | 7.10 |
| CHEMBL1822598 | — | — | 1 | 7.02 |
| CHEMBL1822595 | — | — | 1 | 5.59 |
| CHEMBL1822596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 2.62 | nM | 8.58 |
| CHEMBL1822599 | — | Ki | = | 9.08 | nM | 8.04 |
| CHEMBL1822600 | — | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL1822597 | — | Ki | = | 78.7 | nM | 7.10 |
| CHEMBL1822598 | — | Ki | = | 96.2 | nM | 7.02 |
| CHEMBL1822595 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL1822596 | — | Ki | > | 5000.0 | nM | - |