Assay Detail
Binding
CHEMBL1826230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.44 | 5.02 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1821987 | ENDIANDRAMIDE A | — | 1 | 5.02 |
| CHEMBL1821990 | — | — | 2 | 4.79 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 4.58 |
| CHEMBL1821989 | — | — | 1 | 4.40 |
| CHEMBL1821986 | TSANGIBEILIN B | — | 1 | 4.37 |
| CHEMBL1821993 | — | — | 1 | 4.31 |
| CHEMBL1821985 | TSANGIBEILIN A | — | 1 | 4.30 |
| CHEMBL1821991 | BEILSCHMINOL A | — | 1 | 4.29 |
| CHEMBL1821992 | TSANGIN C | — | 1 | 4.29 |
| CHEMBL1821994 | — | — | 1 | 4.28 |
| CHEMBL1821988 | — | — | 1 | 4.24 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1821987 | ENDIANDRAMIDE A | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL1821990 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 26550.0 | nM | 4.58 |
| CHEMBL1821989 | — | IC50 | = | 39560.0 | nM | 4.40 |
| CHEMBL1821986 | TSANGIBEILIN B | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL1821993 | — | IC50 | = | 48970.0 | nM | 4.31 |
| CHEMBL1821985 | TSANGIBEILIN A | IC50 | = | 49590.0 | nM | 4.30 |
| CHEMBL1821991 | BEILSCHMINOL A | IC50 | = | 51540.0 | nM | 4.29 |
| CHEMBL1821992 | TSANGIN C | IC50 | = | 51420.0 | nM | 4.29 |
| CHEMBL1821994 | — | IC50 | = | 52450.0 | nM | 4.28 |
| CHEMBL1821988 | — | IC50 | = | 58210.0 | nM | 4.24 |
| CHEMBL1821990 | — | Inhibition | - | % | - | |
| CHEMBL227744 | NITROARGININE | IC50 | = | 152460.0 | nM | - |