Assay Detail
Functional
CHEMBL1826331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against vesicular stomatitis virus G-pseudotyped Human immunodeficiency virus 1 NL4-3 infected in human MT2 cells assessed as inhibition of viral replication after 48 hrs by luciferase activity reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.92 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1822611 | — | — | 1 | 9.89 |
| CHEMBL519846 | RO-0622 | 3.0 | 1 | 9.52 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.92 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1822611 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL519846 | RO-0622 | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 47.0 | nM | 7.33 |