Assay Detail
Binding
CHEMBL1826564
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Competitive inhibition of Helicobacter pylori DHQ2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-dehydroquinate dehydratase (CHEMBL4680) ↗| Type | SINGLE PROTEIN |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.42 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823563 | — | — | 1 | 7.30 |
| CHEMBL1823562 | — | — | 1 | 7.01 |
| CHEMBL1823571 | — | — | 1 | 7.00 |
| CHEMBL1823565 | — | — | 1 | 6.85 |
| CHEMBL1823560 | — | — | 1 | 6.69 |
| CHEMBL1823566 | — | — | 1 | 6.58 |
| CHEMBL1823569 | — | — | 1 | 6.55 |
| CHEMBL1823570 | — | — | 1 | 6.55 |
| CHEMBL1823561 | — | — | 1 | 6.51 |
| CHEMBL1823568 | — | — | 1 | 5.96 |
| CHEMBL1823564 | — | — | 1 | 5.17 |
| CHEMBL1823567 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823563 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1823562 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL1823571 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1823565 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1823560 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL1823566 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL1823569 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL1823570 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL1823561 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL1823568 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1823564 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL1823567 | — | Ki | = | 14600.0 | nM | 4.84 |