Assay Detail
Binding
CHEMBL1827135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sterol regulatory element-binding protein 2 (CHEMBL1795166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.50 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824673 | — | — | 1 | 6.00 |
| CHEMBL1621019 | FATOSTATIN | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824673 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1621019 | FATOSTATIN | IC50 | = | 10000.0 | nM | 5.00 |