Compound Detail
CHEMBL1621019
FATOSTATIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1621019 |
| Name | FATOSTATIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZROSUBKIGBSZCG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
2
PK Parameters
6
Publications
0
Known Names
Molecular Properties
294.4
MW (Da)
5.13
ALogP
3
HBA
0
HBD
25.8
PSA (Ų)
0.67
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 2 CHEMBL1795166 | IC50 | 5.25 | 5.125 | 5600.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 606000.0 | mL.min-1.g-1 | Mus musculus |
| T1/2 | 0.1683 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sterol regulatory element-binding protein 2 | IC50 | = | 5600.0 | nM | 5.25 | Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pS... | 21561152 |
| Sterol regulatory element-binding protein 2 | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analy... | 21561152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24967731 | 10.1021/jm500833f | Mycobacterium tuberculosis | 8 |
| 21561152 | 10.1021/jm200304y | Hepatocyte | 3 |
| 21561152 | 10.1021/jm200304y | Sterol regulatory element-binding protein 2 | 2 |
| 21561152 | 10.1021/jm200304y | No relevant target | 2 |
| 21561152 | 10.1021/jm200304y | ADMET | 2 |
| 24967731 | 10.1021/jm500833f | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine