Assay Detail
Functional
CHEMBL1827430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT-2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.68 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823515 | — | — | 1 | 6.54 |
| CHEMBL1823512 | — | — | 1 | 6.27 |
| CHEMBL482690 | — | — | 1 | 6.03 |
| CHEMBL1823511 | — | — | 1 | 6.03 |
| CHEMBL1823516 | — | — | 1 | 5.95 |
| CHEMBL1823513 | — | — | 1 | 5.26 |
| CHEMBL2021513 | — | — | 1 | 5.15 |
| CHEMBL1823514 | — | — | 1 | 4.97 |
| CHEMBL1766195 | — | — | 1 | 4.88 |
| CHEMBL1823510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823515 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1823512 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL482690 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1823511 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL1823516 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL1823513 | — | EC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL2021513 | — | EC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL1823514 | — | EC50 | = | 10730.0 | nM | 4.97 |
| CHEMBL1766195 | — | EC50 | = | 13250.0 | nM | 4.88 |
| CHEMBL1823510 | — | EC50 | > | 85300.0 | nM | - |