Assay Detail
Binding
CHEMBL1827704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of of Bodipy-labelled cyclopamine binding to Smo expressed in COS-1 cells in presence of 20% NHS after 4 to 6 hrs by FACS flow cytometric analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.05 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823864 | — | — | 1 | 7.60 |
| CHEMBL1823863 | — | — | 1 | 7.48 |
| CHEMBL1822468 | — | — | 1 | 7.41 |
| CHEMBL1823865 | — | — | 1 | 6.75 |
| CHEMBL1823591 | — | — | 1 | 6.16 |
| CHEMBL1823862 | — | — | 1 | 6.12 |
| CHEMBL1823861 | — | — | 1 | 5.96 |
| CHEMBL1823857 | — | — | 1 | 5.89 |
| CHEMBL1823860 | — | — | 1 | 5.82 |
| CHEMBL1823841 | — | — | 1 | 5.80 |
| CHEMBL1823859 | — | — | 1 | 5.80 |
| CHEMBL1823584 | — | — | 1 | 5.46 |
| CHEMBL1823855 | — | — | 1 | 5.43 |
| CHEMBL1823843 | — | — | 1 | 5.39 |
| CHEMBL1823616 | — | — | 1 | 5.35 |
| CHEMBL1823858 | — | — | 1 | 5.32 |
| CHEMBL1823854 | — | — | 1 | 5.07 |
| CHEMBL1823844 | — | — | 1 | - |
| CHEMBL1823851 | — | — | 1 | - |
| CHEMBL1823849 | — | — | 1 | - |
| CHEMBL1823848 | — | — | 1 | - |
| CHEMBL1823847 | — | — | 1 | - |
| CHEMBL1823845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823864 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1823863 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1822468 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1823865 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1823591 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1823862 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1823861 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1823857 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1823860 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1823841 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1823859 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1823584 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1823855 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1823843 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1823616 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1823858 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1823854 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1823844 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL1823851 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL1823849 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL1823848 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL1823847 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL1823845 | — | IC50 | > | 2500.0 | nM | - |