Assay Detail
Functional
CHEMBL1827785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSL
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Aliivibrio fischeri |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LuxR (CHEMBL5351) ↗| Type | SINGLE PROTEIN |
| Organism | Aliivibrio fischeri |
Publication
Medicinal chemistry as a conduit for the modulation of quorum sensing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.09 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8799 | — | — | 1 | 6.40 |
| CHEMBL468624 | — | — | 1 | 6.21 |
| CHEMBL259352 | — | — | 1 | 6.11 |
| CHEMBL468790 | — | — | 1 | 6.07 |
| CHEMBL264944 | — | — | 1 | 5.87 |
| CHEMBL584972 | — | — | 1 | 5.87 |
| CHEMBL463321 | — | — | 1 | - |
| CHEMBL8463 | — | — | 1 | - |
| CHEMBL503197 | — | — | 1 | - |
| CHEMBL473592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8799 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL468624 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL259352 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL468790 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL264944 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL584972 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL463321 | — | IC50 | - | — | - | |
| CHEMBL8463 | — | IC50 | - | — | - | |
| CHEMBL503197 | — | IC50 | - | — | - | |
| CHEMBL473592 | — | IC50 | - | — | - |