Assay Detail
Functional
CHEMBL1827786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSL
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Agrobacterium tumefaciens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein TraR (CHEMBL5865) ↗| Type | SINGLE PROTEIN |
| Organism | Agrobacterium tumefaciens |
Publication
Medicinal chemistry as a conduit for the modulation of quorum sensing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.09 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503197 | — | — | 1 | 6.34 |
| CHEMBL584972 | — | — | 1 | 6.16 |
| CHEMBL259352 | — | — | 1 | 6.11 |
| CHEMBL468624 | — | — | 1 | 6.09 |
| CHEMBL264944 | — | — | 1 | 6.04 |
| CHEMBL8799 | — | — | 1 | 5.98 |
| CHEMBL468790 | — | — | 1 | 5.90 |
| CHEMBL463321 | — | — | 1 | - |
| CHEMBL405298 | — | — | 1 | - |
| CHEMBL473592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503197 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL584972 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL259352 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL468624 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL264944 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL8799 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL468790 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL463321 | — | IC50 | - | — | - | |
| CHEMBL405298 | — | IC50 | - | — | - | |
| CHEMBL473592 | — | IC50 | - | — | - |