Assay Detail
Binding
CHEMBL1828296
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Inhibition of KIT activity by TR-FRET assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.67 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823219 | — | — | 1 | 7.30 |
| CHEMBL1779201 | — | — | 1 | 7.08 |
| CHEMBL1823220 | — | — | 1 | 5.62 |
| CHEMBL1823361 | — | — | 1 | - |
| CHEMBL1823223 | — | — | 1 | - |
| CHEMBL1823222 | — | — | 1 | - |
| CHEMBL1823221 | — | — | 1 | - |
| CHEMBL1779202 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823219 | — | IC50 | = | 49.8 | nM | 7.30 |
| CHEMBL1779201 | — | IC50 | = | 83.9 | nM | 7.08 |
| CHEMBL1823220 | — | IC50 | = | 2422.0 | nM | 5.62 |
| CHEMBL1823361 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1823223 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1823222 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1823221 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1779202 | — | IC50 | > | 50000.0 | nM | - |