Assay Detail
Functional
CHEMBL1828312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U87MG after 48 hrs by spectrophotometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.99 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823147 | — | — | 1 | 9.39 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823147 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.6 | nM | 8.59 |