Assay Detail
Binding
CHEMBL1831675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SQ-29548 from human prostanoid TP receptor expressed in QBI-HEK 293A cells after 2 hrs by scintillation proximity assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.32 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65121 | — | — | 1 | 6.85 |
| CHEMBL1829805 | — | — | 1 | 6.69 |
| CHEMBL1829801 | — | — | 1 | 6.48 |
| CHEMBL1829806 | — | — | 1 | 6.48 |
| CHEMBL1829802 | — | — | 1 | 6.45 |
| CHEMBL1829803 | — | — | 1 | 4.94 |
| CHEMBL1828642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65121 | — | Kd | = | 141.0 | nM | 6.85 |
| CHEMBL1829805 | — | Kd | = | 203.0 | nM | 6.69 |
| CHEMBL1829801 | — | Kd | = | 331.0 | nM | 6.48 |
| CHEMBL1829806 | — | Kd | = | 328.0 | nM | 6.48 |
| CHEMBL1829802 | — | Kd | = | 359.0 | nM | 6.45 |
| CHEMBL1829803 | — | Kd | = | 11400.0 | nM | 4.94 |
| CHEMBL1828642 | — | Kd | > | 10000.0 | nM | - |