Assay Detail
Binding
CHEMBL1832155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Na+/H+ exchanger inhibitory activity of benzoylguanidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.27 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829127 | — | — | 1 | 10.17 |
| CHEMBL1829122 | — | — | 1 | 10.14 |
| CHEMBL1829125 | — | — | 1 | 10.08 |
| CHEMBL1829126 | — | — | 1 | 10.04 |
| CHEMBL1829123 | — | — | 1 | 9.96 |
| CHEMBL1829132 | — | — | 1 | 9.51 |
| CHEMBL1829128 | — | — | 1 | 9.28 |
| CHEMBL1829133 | — | — | 1 | 9.25 |
| CHEMBL1829139 | — | — | 1 | 9.17 |
| CHEMBL1829138 | — | — | 1 | 9.04 |
| CHEMBL1829117 | — | — | 1 | 8.97 |
| CHEMBL1829134 | — | — | 1 | 8.96 |
| CHEMBL1829137 | — | — | 1 | 8.82 |
| CHEMBL1789669 | — | — | 1 | 8.74 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 7.51 |
| CHEMBL1829130 | — | — | 1 | 7.31 |
| CHEMBL1829136 | — | — | 1 | 7.25 |
| CHEMBL1829119 | — | — | 1 | 7.03 |
| CHEMBL1829124 | — | — | 1 | 6.90 |
| CHEMBL1829129 | — | — | 1 | 6.86 |
| CHEMBL1829121 | — | — | 1 | 6.85 |
| CHEMBL1829118 | — | — | 1 | 6.81 |
| CHEMBL1829131 | — | — | 1 | 6.65 |
| CHEMBL1829135 | — | — | 1 | 5.82 |
| CHEMBL1829120 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829127 | — | IC50 | = | 0.068 | nM | 10.17 |
| CHEMBL1829122 | — | IC50 | = | 0.073 | nM | 10.14 |
| CHEMBL1829125 | — | IC50 | = | 0.084 | nM | 10.08 |
| CHEMBL1829126 | — | IC50 | = | 0.091 | nM | 10.04 |
| CHEMBL1829123 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL1829132 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1829128 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL1829133 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1829139 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL1829138 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL1829117 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL1829134 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1829137 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1789669 | — | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL1829130 | — | IC50 | = | 49.3 | nM | 7.31 |
| CHEMBL1829136 | — | IC50 | = | 55.7 | nM | 7.25 |
| CHEMBL1829119 | — | IC50 | = | 93.5 | nM | 7.03 |
| CHEMBL1829124 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1829129 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL1829121 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1829118 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL1829131 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL1829135 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL1829120 | — | IC50 | = | 3020.0 | nM | 5.52 |