Assay Detail
Functional
CHEMBL1832164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.34 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830069 | — | — | 1 | 5.40 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.38 |
| CHEMBL1830068 | — | — | 1 | 5.35 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830069 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1830068 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 6000.0 | nM | 5.22 |