Compound Detail
CHEMBL483
TENOFOVIR ANHYDROUS 🧪 Phase III
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL483 |
| Name | TENOFOVIR ANHYDROUS |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | SGOIRFVFHAKUTI-ZCFIWIBFSA-N |
| Active Moiety | CHEMBL258501 |
16
Targets
192
Activities
3
Assay Types
30
PK Parameters
20
Publications
2
Known Names
10
Indications
2
Mechanisms
Molecular Properties
287.2
MW (Da)
-0.05
ALogP
7
HBA
3
HBD
136.4
PSA (Ų)
0.65
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase inhibitor | INHIBITOR | Human immunodeficiency virus type 1 reverse transcriptase | ✓ | ✓ |
| DNA polymerase/reverse transcriptase inhibitor | INHIBITOR | DNA polymerase/reverse transcriptase | ✓ | ✓ |
Indications
Acquired Immunodeficiency Syndrome Carcinoma, Hepatocellular Hepatitis B, Chronic Hepatitis B, Chronic Hepatitis D HIV Infections HIV Infections Infections Severe Acute Respiratory Syndrome Hepatitis C, Chronic
Activity Summary
EC50 139 meas. best 10.19
IC50 52 meas. best 6.42
Kd 1 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis B virus CHEMBL613497 | EC50 | 10.19 | 5.2713 | 0.1 | 24 |
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 8.48 | 5.9955 | 3.3 | 89 |
| Moloney murine leukemia virus CHEMBL613500 | EC50 | 6.64 | 6.64 | 230.0 | 1 |
| Core antigen CHEMBL1075091 | EC50 | 6.62 | 6.62 | 241.5 | 1 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 6.42 | 6.265 | 380.0 | 4 |
| Human immunodeficiency virus 1 CHEMBL378 | IC50 | 6.42 | 5.7021 | 380.0 | 14 |
| Unchecked CHEMBL612545 | IC50 | 6.42 | 6.42 | 380.0 | 1 |
| Hepatitis B virus CHEMBL613497 | IC50 | 6.31 | 5.861 | 490.0 | 10 |
| Human immunodeficiency virus 2 CHEMBL380 | EC50 | 6.06 | 5.526 | 880.0 | 10 |
| MT4 CHEMBL388 | EC50 | 5.85 | 5.745 | 1400.0 | 2 |
| Human immunodeficiency virus CHEMBL613758 | IC50 | 5.8 | 5.7533 | 1600.0 | 3 |
| Porcine endogenous retrovirus CHEMBL613016 | EC50 | 5.55 | 5.55 | 2800.0 | 1 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | Kd | 5.5 | 5.5 | 3200.0 | 1 |
| Human immunodeficiency virus CHEMBL613758 | EC50 | 5.44 | 5.44 | 3600.0 | 1 |
| CCRF-CEM CHEMBL382 | EC50 | 5.43 | 5.43 | 3670.0 | 2 |
| Moloney murine sarcoma virus CHEMBL613501 | EC50 | 5.34 | 5.34 | 4600.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.3 | 5.3 | 5000.0 | 1 |
| CCRF-CEM CHEMBL382 | IC50 | 5.16 | 5.16 | 6900.0 | 1 |
| L1210 CHEMBL386 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
| HeLa CHEMBL399 | IC50 | 4.77 | 4.77 | 17000.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 4.34 | 4.34 | 45800.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 510.8 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 964.7 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1456.1 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 2363.4 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 3039.3 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 5715.4 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 775.2 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1226.9 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 1808.1 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 2790.5 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 3639.5 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 7373.4 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 15779.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 888.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 3.1 | mL.min-1.kg-1 | Homo sapiens |
| CL | 3.1 | mL.min-1.kg-1 | Homo sapiens |
| CL | 5.35 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 172.52 | nM | Rattus norvegicus |
| Cmax | 192.71 | nM | Rattus norvegicus |
| Cmax | 379.85 | nM | Rattus norvegicus |
| Cmax | 519.46 | nM | Rattus norvegicus |
| Cmax | 631.57 | nM | Rattus norvegicus |
| Cmax | 1121.09 | nM | Rattus norvegicus |
| Cmax | 1000.0 | nM | Homo sapiens |
| Cmax | 720.7 | nM | Rattus norvegicus |
| F | 1.41 | % | Rattus norvegicus |
| F | 2.0 | % | Mus musculus |
| Fu | 0.93 | - | Homo sapiens |
| MRT | 3.8 | hr | Homo sapiens |
| T1/2 | 72.0 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine