Assay Detail
Functional
CHEMBL989958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against R5-HIV1MDR/C assessed as inhibition of p24 Gag protein production in human PHA-PBMC by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.22 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517231 | ISLATRAVIR | 3.0 | 1 | 8.40 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.43 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 7.33 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.55 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517231 | ISLATRAVIR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 390.0 | nM | 6.41 |